Oxidative stress-related damage of retinal pigment epithelial cells - possible protective properties of autophagocytosed iron-binding proteins
نویسنده
چکیده
................................................................................................................... 7 LIST OF PAPERS ........................................................................................................... 9 ABBREVIATIONS ....................................................................................................... 10 INTRODUCTION ......................................................................................................... 13 The normal macula ................................................................................................. 13 Age-related macular degeneration .......................................................................... 15 Prevalence and risk factors .............................................................................. 15 Classification .................................................................................................... 15 The retinal pigment epithelium .............................................................................. 18 General concepts of AMD pathogenesis ................................................................ 19 Oxidative stress-related injury ......................................................................... 19 Structural changes in Bruch’s membrane ........................................................ 20 Inflammation .................................................................................................... 20 Lysosomes .............................................................................................................. 21 Autophagy ......................................................................................................... 22 Iron .......................................................................................................................... 24 Oxidative stress....................................................................................................... 26 Oxygen metabolism .......................................................................................... 26 Reactive oxygen species and free radicals ....................................................... 27 Lipid peroxidation ............................................................................................ 29 Lipofuscin ......................................................................................................... 30 Protective anti-oxidant mechanisms ................................................................ 31 Lysosomal membrane permeabilization ........................................................... 34 Experimental models for AMD .............................................................................. 36 Methods for exposure to oxidative stress ............................................................... 37 DCF ........................................................................................................................ 37
منابع مشابه
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Oxidative stress damage to retinal pigment epithelial (RPE) cells is thought to play a critical role in the pathogenesis of age-related macular degeneration (AMD). Crocin, a pharmacologically active component of Crocus sativus L., was reported to have anti-antioxidant and anti-apoptotic properties. However, whether crocin protects against oxidative stress-induced retinal damage in RPE cells is ...
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